Osteoarthritis

Hyalgan Vs.Synvisc

Hyalgan and Synvisc are medications used to treat the knee discomfort associated with joint inflammation. Many doctors use it for patients who suffer with one of the many forms of arthritis, particularly osteoarthritis. Osteoarthritis is the most common cause of knee pain. The pain of the joint is the direct result of the smooth cartilage of the joint wearing thin.

These solutions are generally reserved for people who do not respond to conservative therapies such as medications like acetaminophen, exercise, and physical therapy. Because Hyalgan and Synvisc are similar to a naturally occurring substance in the joints, they work by acting as shock absorbers and lubricants for the joint. This allows for a smooth motion of the joint, and therefore, a reduction in pain.

Difference Number 1: Composition

The active component of Synvisc is hyaluronate, also known as hyaluronan. This solution is injected into joints to help them move smoothly, therefore decreasing pain and stiffness. Hyaluronate is a substance similar to the fluid inside the joint. Synvisc is a gel-type mixture made up of hylan A fluid, hylan B gel, and a salt water solution. Hyaluronate is a natural complex sugar from the glycosaminoglycan family. This long-chain polymer contains repeating disaccharide units of Na-clucuronate-N-acetylglucosamine. The Hyalgan product comes from hyaluronan, as well. Hyalgan is a viscous solution derived of purified natural sodium hyaluronate. This viscous solution has a high molecular weight.

Difference Number 2: Manufacturer

Synvisc is a registered trademark of the Genzyme Corporation in the United States, where Hylagan is a brand of the Fidia Farmaceutici Corporation in Italy.

Difference Number 3: How it is Given

Synvisc is typically given in a series of 3 injections, approximately 3 weeks apart. You may not experience significant relief until you have your second or third injection. Some patients report relief after the first injection however. Hylagan, on the other hand, is a 5 injection regimen that is given at weekly intervals. Some patients report benefits after only 2 or 3 injections.

Similarity Number 1: Mechanism of Action

Both Hylagan and Synvisc work the same way. The exact way, however, is not known. Experts believe that these substances act as lubricants and shock absorbers in the joint to allow it to glide smoothly through range of motion. With osteoarthritis there is not enough natural hyaluronan in the joint and the addition of Synvisc or Hylagan into the joint alleviates this problem.

Similarity Number 2: Where it Comes From

Both Hylagan and Synvisc are composed of hyaluronate. The hyaluronate is extracted from rooster combs, a type of fleshy growth found on the upper portion of chicken heads. The comb substance is put in a solution buffered in physiological sodium chloride.

Similarity Number 3: Side Effects

The side effects of Synvisc and Hylagan are the same. These include pain, redness, warmth, and swelling. Both are equally likely to cause a severe anaphylactic reaction. You should notify the doctor immediately if you experience a fast, pounding heartbeat, difficulty breathing, tingling skin, dizziness, or itching.

Monovisc, osteoarthritis treatment by Anika Therapeutics

Monovisc is an exclusive treatment for osteoarthritis created by Anika Therapeutics, the makers of Orthovisc. It is the only single-injection viscosupplement approved for the relief of joint pain associated with arthritis. The medication is specially formulated as a single-injection treatment, giving enhanced durability with one easy-to-use, safe injection. Other viscosupplements require 3 to 5 injections for the same treatment. It offers lower cost to the patient, convenience, decreased office visits, and reduction in the risk associated with multiple injections.

Monovisc is made from non-animal, purified, natural hyaluronan, a substance that occurs naturally throughout the body. Hyaluronan is located in larger quantities in articular cartilage, synovial fluid in the joints, and in the skin.

Mechanism of Action

Monvisc is a high molecular weight polysaccharide composed of sodium glucuronate and N-acetylglucosamine. The exact mechanism of action is not known, but experts believe that Monvisc works by functioning to lubricate the joint, provide mechanical support, and work as a shock absorber.

How to Use Monovisc

The medication should be administered by a licensed healthcare professional, typically a doctor or advanced practice clinician. The doctor will inject this medication into your affected joint after cleansing the area with a skin disinfectant.

This medication should not be injected into an artery or vein, as serious side effects could occur. You should not attempt to administer the medication at home. Keep this product, along with needles and syringes, out of reach of children. Do not open the package and expose the sterile solution.

Your doctor will advise you on your activity level once you have received an injection of Monovisc. Typically, you are instructed not to stand on your feet for more than an hour, and no jogging, running, or heavy lifting for at least 48 hours. Also, following a Monovisc injection, expect mild pain and swelling at first. Should this continue or not improve, tell your doctor.

An additional patient booklet is available with Monovisc. Ask your pharmacist or doctor to give it to you so you can read more about this medication. Be sure to inquire with your doctor should you have any questions related to the medication.

Monovisc Side Effects

You should notify your doctor if the following side effects persist or worsen:

  • Pain
  • Redness
  • Warmth
  • Swelling

Immediately following the injection, report any of the following:

  • Fast and pounding heartbeat
  • Rash
  • Itching
  • Difficulty breathing
  • Dizziness
  • Severe headache
  • Tingling Skin
  • Swelling of the face, tongue, or throat

Precautions

You should advise your doctor if you are allergic to Monovisc or any substance similar to it. Also, report any allergies to bird feathers, eggs, or bird protein. It is wise to report any allergies you have to your doctor.

Prior to receiving an injection, report any joint infections, skin infections, skin conditions, circulation problems, or other pertinent medical information.

At present, researchers are unsure if the medication passes into breast milk, so advise your doctor if you are breast-feeding. You should also consult your doctor if you are pregnant or plan on becoming pregnant.

It is relevant that you advise your doctor on any medications you are currently taking. Quaternary ammonium salts, such as benzalkonium chloride, should not be used in conjunction with Monovisc.

Hyalgan – hyaluronate sodium injection

Hyalgan is a medication used to treat the knee pain associated with joint inflammation. Many doctors use it for patients who suffer with one of the many forms of arthritis, particularly osteoarthritis. This medication is typically reserved for those patients who do not respond to conventional treatments such as exercise, physical therapy, or acetaminophen. Because Hyalgan is similar to a naturally occurring substance in the joints, it works by acting as a shock absorber and lubricant for the joint. This allows for a smooth motion of the joint, and therefore, a reduction in pain.

Hyalgan is a viscous solution derived of purified natural sodium hyaluronate. The hyaluronate, extracted from rooster combs, is buffered in physiological sodium chloride. Hyaluronate is a natural complex sugar from the glycosaminoglycan family. This long-chain polymer contains repeating disaccharide units of Na-clucuronate-N-acetylglucosamine.

 Mechanism of Action

The exact mechanism of action of Hyalgan is unknown; however, the proposed activity mechanisms include:

Replacement – Hyalgan replaces and improves viscosity. By adding Hyalgan to the joint synovial fluid, the concentration of fluid increases making joint movement smoother.

Restoration – Hyalgan restores the shock-absorbing, lubricating ability of the depleted synovial fluid

Maintenance – Hyalgan maintains the boundary layer around the nociceptors, therefore reducing pain.

How to Use Hyalgan

Also called hyaluraonate, Hyalgan should be administered by a licensed healthcare professional, typically a doctor of advanced practice clinician. The provider will inject this medication into your affected joint after cleansing the area with a skin disinfectant.

Hyalgan is generally given in a series of 3 to 5 injections, approximately 1-2 weeks apart. You may not experience significant relief until you have  your second or third injection. Some patients report relief after the first injection, however.

This medication should not be injected into an artery or vein, as serious side effects could occur. You should not attempt to administer Hyalgan at home. Keep this product, along with needles and syringes, out of reach of children. Do not open the package and expose the sterile solution.

Your doctor will advise you on your activity level once you have received an injection of Hyalgan. Typically, you are instructed not to stand on your feet for more than an hour, and no jogging, running, or heavy lifting for at least 48 hours. Also, following a Hyalgan injection, expect mild pain and swelling at first. Should this continue or not improve, tell your doctor.

An additional patient booklet is available with Hyalgan. Ask your pharmacist or doctor to give it to you so you can read more about this medication. Be sure to inquire with your doctor should you have any questions related to Hyalgan.

Hyalgan Side Effects

You should notify your doctor if the following side effects persist or worsen:

  • Pain
  • Redness
  • Warmth
  • Swelling

Immediately following the injection, report any of the following:

  • Fast and pounding heartbeat
  • Rash
  • Itching
  • Difficulty breathing
  • Dizziness
  • Severe headache
  • Tingling Skin
  • Swelling of the face, tongue, or throat

Hyalgan Precautions

You should advise your doctor if you are allergic to Hyalgan or any substance similar to it. Also, report any allergies to bird feathers, eggs, or bird protein. It is wise to report any allergies you have to your doctor.

Prior to receiving an injection of Hyalgan, report any joint infections, skin infections, skin conditions, circulation problems, or other pertinent medical information.

At present, researchers are unsure if Hyalgan passes into breast milk, so advise your doctor if you are breast-feeding. You should also consult your doctor if you are pregnant or plan on becoming pregnant.

It is relevant that you advise your doctor on any medications you are currently taking. Quaternary ammonium salts, such as benzalkonium chloride, should not be used in conjunction with Hyalgan.